Fear conditioning, extinction and extinction recall as a model for EMDR therapy in humans and animals

Description

Disruption of fear processing seems to be at the core of posttraumatic stress disorders (PTSD). Indeed, mechanisms of fear conditioning, extinction and extinction recall have been found to be disrupted in PTSD patients. We have demonstrated that such deficits (especially fear extinction delay) disappear after EMDR therapy according to behavioral responses as well as psychophysiological measures (skin conductance, response, heart rate). In addition, using fMRI, we observed brain activities modification during fear condition and extinction in PTSD after EMDR as compared to before EMDR, in prefrontal and limbic structures notably.

Considering these results, we used the fear conditioning, extinction and recall paradigm to test for the specific effect of bilateral alternate stimulations (BAS) during extinction to mimic the EMDR therapy. In both healthy human subjects and mouse, fear extinction and/or extinction recall were facilitated in presence of BAS as compared to without BAS.

This paradigm could therefore constitute a valuable model to explore the EMDR mechanisms of action especially BAS effect not only in humans but also for the first time in animals.

Format

Conference

Language

English

Author(s)

Stephanie Khalfa

Original Work Citation

Khalfa, S. (2014, June). Fear conditioning, extinction and extinction recall as a model for EMDR therapy in humans and animals. In EMDR neurobiology research symposium (Peter Liebermann, Chair). Symposium presented at the 15th EMDR Europe Association Conference, Edinburgh, Scotland

Collection

Citation

“Fear conditioning, extinction and extinction recall as a model for EMDR therapy in humans and animals,” Francine Shapiro Library, accessed April 18, 2021, https://emdria.omeka.net/items/show/22894.

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