Basal blood DHEA-S/cortisol levels predicts EMDR treatment response in adolescents with PTSD

0803-9488.png

Description

Objective:
In literature, recent evidence has shown that the hypothalamic-pituitary-adrenal (HPA) axis can be dysregulated in patients with post-traumatic stress disorder (PTSD) and HPA axis hormones may predict the psychotherapy treatment response in patients with PTSD. In this study, it was aimed to investigate changing cortisol and DHEA-S levels post-eye movement desensitization and reprocessing (EMDR) therapy and the relationship between treatment response and basal cortisol, and DHEA-S levels before treatment.

Method:
The study group comprised 40 adolescents (age, 12-18 years) with PTSD. The PTSD symptoms were assessed using the Child Depression Inventory (CDI) and Child Post-traumatic Stress Reaction Index (CPSRI) and the blood cortisol and DHEA-S were measured with the chemiluminescence method before and after treatment. A maximum of six sessions of EMDR therapy were conducted by an EMDR level-1 trained child psychiatry resident. Treatment response was measured by the pre- to post-treatment decrease in self-reported and clinical PTSD severity.

Results:
Pre- and post-treatment DHEA-S and cortisol levels did not show any statistically significant difference. Pre-treatment CDI scores were negatively correlated with pre-treatment DHEA-S levels (r: -0.39). ROC analysis demonstrated that the DHEA-S/cortisol ratio predicts treatment response at a medium level (AUC: 0.703, p: .030, sensitivity: 0.65, specificity: 0.86).

Conclusion:
The results of this study suggested that the DHEA-S/cortisol ratio may predict treatment response in adolescents with PTSD receiving EMDR therapy. The biochemical parameter of HPA-axis activity appears to be an important predictor of positive clinical response in adolescent PTSD patients, and could be used in clinical practice to predict PTSD treatment in the future..

Format

Journal

Author(s)

Mirac Baris Usta
Yusuf Yasin Gumus
Gokce Nur Say
Abdullah Bozkurt
Bberkan Şahin
Koray Karabekiroğlu

Original Work Citation

Usta,  M. B., Gumus, Y. Y., Say, G. N., Bozkurt, A., Şahin, B., &  Karabekiroğlu, K. (2018, April).  Basal blood DHEA-S/cortisol levels predicts EMDR treatment response in adolescents with PTSD.  Nordic Journal Of Psychiatry, 72(3), 164-172. doi:10.1080/08039488.2017.1406984

Collection

Citation

“Basal blood DHEA-S/cortisol levels predicts EMDR treatment response in adolescents with PTSD,” Francine Shapiro Library, accessed September 16, 2021, https://emdria.omeka.net/items/show/24711.

Output Formats